At least two people died and seven were injured but it is feared that others are trapped under the mound of debris in the city's Kartal district.
The building was officially home to 43 people living in 14 flats, Istanbul Governor Ali Yerlikaya said.
It is still not known what caused the disaster on Wednesday afternoon.
According to the governor, the top three storeys of the building had been added illegally.
A textile workshop on the building's lower floor was empty at the time, local official Zeki Dag told local media earlier.
Firefighters, medics and police officers rushed to the scene.
As they searched the pile of rubble, rescuers occasionally appealed for quiet to listen for any sounds coming from underneath that might indicate trapped survivors.
from Latest News - SUCH TV http://bit.ly/2DdhbrE
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